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L-Glutamine – The Miracle Amino Acid and How You Can Benefit From Its Use
I don’t believe in miracles – I depend on them. – Raymond Dale
I am completely confused… For some strange reason glutamine or L-Glutamine as it was officially baptized, like today was not really discovered by the world at large! What do I mean when I find out? Well, it seems strange to me that an amino acid that makes up a large portion of your skeletal muscle mass and is depleted by daily exertion and physical exertion does not play a major role in the repair, recovery and general maintenance of… well over 60% of your body. Glutamine is an amino acid found in the proteins of all life forms and is classified as an essential or conditionally essential amino acid. This means that under normal conditions the body can synthesize enough L-glutamine to meet the body’s needs. However, there are situations where the body cannot do that. So my problem is, should I open the floodgates and shout to the world how important glutamine is or should I contribute to suppressing what I see as one of the most important elements necessary for physical integrity and overall health? I’m going to do what I do and that’s tell the truth, and I’m going to let you see how important glutamine is for you. It’s ok? So much!
Recently, glutamine has been called an essential amino acid when the body is under conditions of metabolic stress such as shock (including surgical trauma), cancer, sepsis and burns, this list also includes trauma or overuse such as heavy- Core training in athletics, stress of emotions and the daily grind of a hard lifestyle, I couldn’t agree more. Under these conditions, L-glutamine becomes an essential amino acid, and therefore it is very important to ensure an adequate intake or amino acid replacement to meet the growing physical and mental needs created by these conditions. But again, with all the physiological, psychological and can we even talk about low air pressure…my personal assessment (guess) is that glutamine is more important for us than those in positions of power, Persuasion and strength can make us believe. Common sense dictates that if we break up quickly, often and do so often… well there is just a system already in place to take care of us… just think!
Fortunately glutamine is indeed and without controversy the most abundant amino acid found in the body, (thank goodness science) and plasma (blood) levels of glutamine are the highest of any amino acid. Glutamine is synthesized and stored in skeletal muscle. The amino acid L-glutamate is metabolized to L-glutamine in a reaction catalyzed (Starting a chemical reaction and able to continue under different conditions) by the enzyme glutamine synthase, a reaction which, in addition to L-glutamate, requires ammonia . , ATP and magnesium…ya’ dig?
And if that’s not interesting enough, glutamine is also a multi-purpose amino acid and participates in many reactions in the body. Glutamine is very important in the management of acid-base balance and glutamine allows the kidneys to remove the acid load, protecting the body from acidosis. This is achieved by the production of ammonia, which binds hydrogen ions, producing ammonium cations (a positively charged polyatomic ion of the chemical formula NH4 + with a molecular mass of 18.04, resulting from the protonation of ammonia ( NH3).) urine and chloride anions. Bicarbonate ions are simultaneously released into the blood. If that’s not strong enough, check this out… glutamine helps protect the body from ammonia toxicity by transporting ammonia, in the form of the amide group of glutamine, from peripheral tissues to visceral organs, where it can be excreted as ammonium. in the kidneys or converted to urea by the liver. Sorry about the science mumbo-jumbo, but because I wholeheartedly feel that glutamine is very important, I only think it is good to convey these messages, so without delay … a little … gibberish).
This miracle amino acid also participates in other metabolic activities such as; acting as an important transporter of nitrogen, supplying nitrogen for metabolic purposes (from tissues that produce glutamine, such as skeletal muscle) to tissues that consume glutamine. Pretty cool huh? That’s not the whole shebang, please continue.
Besides all those good things, glutamine also participates in the formation of purine and pyrimidine nucleotides, amino sugars (such as glucosamine), L-glutamate and other amino acids, nicotinamide adenine dinucleotide and and glutathione. As well as participating in protein synthesis, energy production and, if necessary, the production of D-glucose and glycogen. Importantly, glutamine can act as the main element of respiration (Things or something where the enzyme works or the place where the organism grows or is attached) for the production of energy in enterocytes and lymphocytes. Glutamine is considered an immunonutrient, and additional L-glutamine is used in medical food in conditions such as the stress mentioned above, cancer, infection and burns and post-burn infections of all degrees.
Supplemental glutamine’s possible immunomodulatory role can be explained in several ways. Glutamine appears to play a major role in protecting the integrity of the gastrointestinal tract and, in particular, the large intestine. During catabolic conditions, the integrity of the intestinal mucosa can be disturbed due to the increase in intestinal flora and the transfer of Gram-negative bacteria from the large intestine to the body. The demand for glutamine by the intestine, and by cells such as lymphocytes, appears to be much greater than that provided by skeletal muscle, a large tissue for storing glutamine, adding glutamine is the preferred substance for the respiration of enterocytes, colonocytes and lymphocytes. . Therefore, providing supplemental glutamine under these conditions can do many things. On the other hand, it is possible to change the catabolic state by preserving the glutamine of the skeletal muscle. It can also inhibit the migration of Gram-negative bacteria from the large intestine. Glutamine helps maintain IgA secretion, which works primarily by preventing the adhesion of bacteria to mucosal cells.
There is now significant evidence linking glutamine-enriched foods with good bowel effects; supporting and maintaining intestinal barrier function, proliferation of intestinal cells, and helping to generally reduce septic illness. The reason for that cleaning property is thought to come from the fact that the rate of intestinal absorption of glutamine is higher than other amino acids and then it is thought to be the most effective option when trying to reduce conditions related to the intestines. These conditions were found after comparing plasma concentrations in the stomach between glutamine enriched and non-glutamine enriched foods. However, although glutamine is thought to have cleansing properties and effects, it is not known how much clinical benefit it has, due to the concentration of glutamine in a variety of foods.
Moreover, glutamine seems to be required to support the proliferation of mitogen-stimulated lymphocytes, and the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). It is also needed to maintain lymphokine-activated killer cells (LAK). Glutamine can improve phagocytosis by neutrophils and monocytes. It can lead to an increase in glutathione in the gut, which may also play a role in maintaining the integrity of the intestinal mucosa by reducing oxidative stress.
But the exact mechanism of the immunomodulatory action of supplemental glutamine on the other hand, remains unresolved. My guess is that it is more than expected that the main effect of glutamine occurs at the level of the intestine (stomach). And perhaps the enteral glutamine works clearly on the lymphoid tissue associated with the intestine and stimulates the activity of the whole body in that way, without passing beyond the splanchnic bed.
Glutamine Reduces Post-Burn Infections
According to a recent study in Critical Care Medicine (2003;31:2444-9) glutamine reduces the risk of infection and may lead to fewer deaths and shorter hospital stays in burn victims. In the study, 41 adults under the age of 65 with severe burns covering between 20 and 80% of their skin were assigned to receive standard nutrition using a food tube supplemented with 4.3 grams of glutamine or supplemented with other amino acids. acids (aspartic acid), asparagine, and glycine) every four hours (up to 26 grams per day). Treatment was continued until the burn was completely healed. Time spent in hospital, incidence of sepsis, and mortality were recorded.
The incidence of blood infections was three times higher in people who received the control mixture than those who received supplemental glutamine in their feeding tube. There were no deaths in the group receiving glutamine among the 19 people who survived the first 72 hours, compared to eight deaths among the 16 people in the control group who survived the first 72 hours. The time spent in the hospital was significantly reduced for those receiving glutamine.
The anticatabolic / anabolic function of extra glutamine can be explained by its effect and its effectiveness in protecting the glutamine stores of skeletal muscle.
Glutamine powder is a tasteless, easily mixed, pure, amino acid free powder.
What can it do to you…
Clinical studies reveal that glutamine supplementation can help support recovery after intense training by promoting energy replenishment, maintaining a healthy immune system and increasing your body’s defenses against lactic acid build-up.
Also, glutamine is the most abundant amino acid found in your muscles – over 6o% of skeletal muscle is actually glutamine. It contains 19% nitrogen, making it the main transporter of nitrogen to your muscle cells. During extreme training, the levels of glutamine in your body decrease significantly, which reduces energy, strength and recovery. It may take up to a week for glutamine levels to return to normal. Glutamine supplementation can reduce muscle breakdown and improve protein metabolism.
In addition to playing a key role in protein metabolism, cell volumizing and anti-catabolism, glutamine will increase your ability to produce Human Growth Hormone, which helps metabolize body-fat and supports the growth of new body tissues. Glutamine’s anti-catabolism has the ability to prevent the deterioration of the integrity of your muscles. This is especially useful for those who are ‘sick’. Especially in the spring to summer when you’re trying to shed unwanted body fat, without losing any hard-earned muscle.
Especially because glutamine levels are depleted during exercise, bodybuilders are more susceptible to illnesses and that is why glutamine supplementation is very important, not necessarily to gain more muscles, but to maintain muscle integrity and physical strength and because the addition of glutamine promotes well-being. nitrogen balance and prevents muscle loss. A recent study has shown that taking just 2 grams of glutamine can increase growth hormone levels by 400%.
Now, if all this is not enough evidence for you to do a little research of your own, then I don’t know what to say’, but if I contributed to awakening your interest in glutamine, I did what I did. you are willing to do…and that is conveying the TRUTH! Here’s to you, your strength and truth. – Know Yourself!
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